Microcalorimeters

TA Instruments’ Isothermal Titration Calorimetry (ITC), Differential Scanning Calorimetry (DSC), and Isothermal Calorimetry systems are powerful analytical techniques for in-depth characterization of molecular binding events and structural stability. Thermodynamic binding signatures not only reveal the strength of a binding event, but the specific or nonspecific driving forces involved.

Structural stability profiles from DSC reveal strengths and weaknesses in higher order structure and define the behavior of individual domains and their interactions. The TA Instruments Affinity ITC, Nano ITC and Nano DSC provide the performance, reliability and ease-of-use required for the most demanding applications in drug discovery, protein-protein interactions, structure-function characterization and more.

Differential Scanning Calorimetry - Nano DSC

The Nano DSC differential scanning calorimeter is designed to characterize the molecular stability of dilute in-solution biomolecules. The Nano DSC obtains data using less sample than competitive designs. Solid-state thermoelectric elements are used to precisely control temperature and a built-in precision linear actuator maintains constant or controlled variable pressure in the cell. Automated, unattended continuous operation with increased sample throughput is achieved with the optional Nano DSC Autosampler.

Isothermal Titration Calorimetry - Nano ITC

The Nano ITC Standard Volume and Nano ITC Low Volume isothermal titration calorimeters are designed to provide maximum sensitivity and flexibility for the study of biomolecular binding. Both instruments use solid state thermoelectric heating and cooling systems to precisely control temperature, and have the same flexible injection syringe assemblies for efficient and accurate delivery of titrant. The true isothermal power compensation design of the Nano ITC instruments provides the highest sensitivity and flexibility for an ultrasensitive ITC analyzing biological samples in-solution.

Isothermal Microcalorimetry - TAM IV

All chemical, physical and biological processes are associated with a heat production or heat consumption.

TAM IV is the most sensitive, stable and flexible microcalorimeter system in the world for directly measuring this universal heat signal and, therefore, the quantitative thermodynamic and kinetic observation of any process. It is a unique microcalorimeter system that is completely modular and combines the highest heat flow sensitivity with unmatched long term temperature stability for measuring many processes that are undetectable by other techniques. A wide range of calorimeter configurations and sample handling systems provide maximum application flexibility and ensure optimum laboratory productivity.

TAM IV - The World's Most Sensitive Calorimeter System : https://youtu.be/a5w4VJAExhU